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Comparison of Iron Oxide Nanoparticles in Photothermia and Magnetic Hyperthermia: Effects of Clustering and Silica Encapsulation on Nanoparticles’ Heating Yield

19 oct. 2020Applied Sciences

DOI : 10.3390/app10207322

Auteurs

Sebastjan Nemec, Slavko Kralj, Claire Wilhelm, Ali Abou-Hassan, Marie-Pierre Rols, Jelena Kolosnjaj-Tabi

Résumé

Photothermal therapy is gathering momentum. In order to assess the effects of the encapsulation of individual or clustered superparamagnetic iron oxide nanoparticles (SPIONs) on nanoparticle light-to-heat conversion, we designed and tested individual and clustered SPIONs encapsulated within a silica shell. Our study compared both photothermia and magnetic hyperthermia, and it involved individual SPIONs as well as silica-encapsulated individual and clustered SPIONs. While, as expected, SPION clustering reduced heat generation in magnetic hyperthermia, the silica shell improved SPION heating in photothermia.

Membres

CLAIRE WILHELM

Directeur de recherche CNRS