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- The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma
The E-cadherin-ESR1-GRPR axis defines a sex-specific metastatic pathway in melanoma
Auteurs
Jérémy H. Raymond, Marie Pouteaux, Valérie Petit, Zackie Aktary, Flavie Luciani, Maria Wehbe, Patrick Gizzi, Claire Bourban, Igor Martianov, Irwin Davidson, Catherine-Laure Tomasetto, Florence-Mahuteau Betzer, Béatrice Vergier, Lionel Larue, Véronique Delmas
Résumé
Summary
Although tremendous progress has been made in understanding the mechanisms leading to cancer, those governing metastases are still poorly understood. E-cadherin (Ecad) is a cell-cell adhesion molecule essential for tissue homeostasis, and its loss often correlates with the dissemination of human cancers. However, whether and how the loss of Ecad triggers the full metastatic program is largely unknown. Here, we show that the loss of Ecad promotes melanoma lung metastases in females. The loss of Ecad, after the induction of estrogen receptor α (ERα) expression, activates gastrin-releasing peptide receptor (GRPR) expression. GRPR promotes cellular processes essential for metastasis formation through G□
Membres

VALERIE PETIT
Ingénieur de recherche