Transmission of innate immune signaling by packaging of cGAMP in viral particles

Science
Matteo Gentili, Joanna Kowal, Mercedes Tkach, Takeshi Satoh, Xavier Lahaye, Cécile Conrad, Marilyn Boyron, Bérangère Lombard, Sylvère Durand, Guido Kroemer, Damarys Loew, Marc Dalod, Clotilde Théry, Nicolas Manel
DOI
10.1126/science.aab3628
Abstract

Viruses pack antiviral mediators

Viruses often hijack host proteins for their own use, turning host cells into virion-spewing machines. However, Bridgeman
et al.
and Gentili
et al.
now report a sneaky way that the host can fight back (see the Perspective by Schoggins). Host cells that expressed the enzyme cGAS, an innate immune receptor that senses cytoplasmic DNA, packaged the cGAS-generated second messenger cGAMP into virions. Virions could then transfer cGAMP to neighboring cells, triggering an antiviral gene program in these newly infected cells. Such transfer of an antiviral mediator may help to speed up the immune response to put the brakes on viral spread.

Science
, this issue pp.
1228
and
1232
; see also p.
1166

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