OLENA PYLYPENKO

Docteur,

Chargé de recherche CNRS

Recherche - Paris

Spécialités / domaines

Biochimie,

Biologie moléculaire,

Biologie structurale,

Cristallographie de protéines,

Physique-chimie-biologie multi-échelle et cancer (molécules, cellules, tissus et organismes)

Fonctions au sein de l'Institut Curie :

Chercheur permanent

Dynamique de l'organisation intracellulaire
Unité : Biologie cellulaire et Cancer (UMR144)

Publications

2021

Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance

Oncogene

Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Hélène Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bièche, Marie-Lise Lacombe, Ana Maria Eiján, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan

(2021 juin 10)

2020

Force Generation by Myosin Motors: A Structural Perspective

Chemical Reviews

Julien Robert-Paganin, Olena Pylypenko, Carlos Kikuti, H. Lee Sweeney, Anne Houdusse

(2020 jan 08)

2019

Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif

Scientific Reports

Fernando Vilela, Christophe Velours, Mélanie Chenon, Magali Aumont-Nicaise, Valérie Campanacci, Aurélien Thureau, Olena Pylypenko, Jessica Andreani, Paola Llinas, Julie Ménétrey

(2019 déc 01)

2018

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity

Small GTPases

Olena Pylypenko, Hussein Hammich, I-Mei Yu, Anne Houdusse

(2018 Mar 04)

2018

MYO5B,STX3, andSTXBP2mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update

Human Mutation

Herschel S. Dhekne, Olena Pylypenko, Arend W. Overeem, Rosaria J. Ferreira, K. Joeri van der Velde, Edmond H.H.M. Rings, Carsten Posovszky, Morris A. Swertz, Anne Houdusse, Sven C.D. van IJzendoorn

(2018 Mar 01)

2017

Coupling fission and exit of RAB6 vesicles at Golgi hotspots through kinesin-myosin interactions

Nature Communications

Stéphanie Miserey-Lenkei, Hugo Bousquet, Olena Pylypenko, Sabine Bardin, Ariane Dimitrov, Gaëlle Bressanelli, Raja Bonifay, Vincent Fraisier, Catherine Guillou, Cécile Bougeret, Anne Houdusse, Arnaud Echard, Bruno Goud

(2017 déc 01)

2017

Oxidation of F-actin controls the terminal steps of cytokinesis

Nature Communications

Stéphane Frémont, Hussein Hammich, Jian Bai, Hugo Wioland, Kerstin Klinkert, Murielle Rocancourt, Carlos Kikuti, David Stroebel, Guillaume Romet-Lemonne, Olena Pylypenko, Anne Houdusse, Arnaud Echard

(2017 avr 01)

2016

The myosin X motor is optimized for movement on actin bundles

Nature Communications

Virginie Ropars, Zhaohui Yang, Tatiana Isabet, Florian Blanc, Kaifeng Zhou, Tianming Lin, Xiaoyan Liu, Pascale Hissier, Frédéric Samazan, Béatrice Amigues, Eric D. Yang, Hyokeun Park, Olena Pylypenko, Marco Cecchini, Charles V. Sindelar, H. Lee Sweeney, Anne Houdusse

(2016 nov 01)

2016

Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

eLife

Olena Pylypenko, Tobias Welz, Janine Tittel, Martin Kollmar, Florian Chardon, Gilles Malherbe, Sabine Weiss, Carina Ida Luise Michel, Annette Samol-Wolf, Andreas Till Grasskamp, Alistair Hume, Bruno Goud, Bruno Baron, Patrick England, Margaret A Titus, Petra Schwille, Thomas Weidemann, Anne Houdusse, Eugen Kerkhoff

(2016 Sep 13)

2016

Force-producing ADP state of myosin bound to actin

Proceedings of the National Academy of Sciences

Sarah F. Wulf, Virginie Ropars, Setsuko Fujita-Becker, Marco Oster, Goetz Hofhaus, Leonardo G. Trabuco, Olena Pylypenko, H. Lee Sweeney, Anne M. Houdusse, Rasmus R. Schröder

(2016 Mar 29)