Equipe Bellaïche

All our publications

Leroy O, van Leen E, Girard P, Villedieu A, Hubert C, Bosveld F, Bellaïche Y, Renaud O. Multi-view confocal microscopy enables multiple organ and whole organism live-imaging. Development. 2022 Jan 24:dev.199760. doi: 10.1242/dev.199760. Epub ahead of print. PMID: 35072204.

di Pietro F, Herszterg S, Huang A, Bosveld F, Alexandre C, Sancéré L, Pelletier S, Joudat A, Kapoor V, Vincent JP, Bellaïche Y. Rapid and robust optogenetic control of gene expression in Drosophila. Dev Cell. 2021 Dec 20;56(24):3393-3404.e7. doi: 10.1016/j.devcel.2021.11.016. Epub 2021 Dec 7. PMID: 34879263; PMCID: PMC8693864.

Park S, Matte-Martone C, Gonzalez DG, Lathrop EA, May DP, Pineda CM, Moore JL, Boucher JD, Marsh E, Schmitter-Sánchez A, Cockburn K, Markova O, Bellaïche Y, Greco V. Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Nat Cell Biol. 2021 May;23(5):476-484. doi: 10.1038/s41556-021-00670-5. Epub 2021 May 6. PMID: 33958758; PMCID: PMC8603572.

López-Gay JM, Nunley H, Spencer M, di Pietro F, Guirao B, Bosveld F, Markova O, Gaugue I, Pelletier S, Lubensky DK, Bellaïche Y. Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue. Science. 2020 Oct 16;370(6514):eabb2169. doi: 10.1126/science.abb2169. PMID: 33060329.

Yu JJS, Maugarny-Calès A, Pelletier S, Alexandre C, Bellaiche Y, Vincent JP, McGough IJ. Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands. Dev Cell. 2020 Sep 14;54(5):583-592.e5. doi: 10.1016/j.devcel.2020.08.004. Epub 2020 Sep 3. PMID: 32888416; PMCID: PMC7497783.

Villedieu A, Bosveld F, Bellaïche Y. Mechanical induction and competence in epithelial morphogenesis. Curr Opin Genet Dev. 2020 Aug;63:36-44. doi:10.1016/j.gde.2020.03.003. Epub 2020 May 5. PMID: 32387999.

Bosveld F, Bellaïche Y. Tricellular junctions. Curr Biol. 2020 Mar 23;30(6):R249-R251. doi: 10.1016/j.cub.2020.01.029. PMID: 32208143.

Edwards-Jorquera SS, Bosveld F, Bellaïche YA, Lennon-Duménil AM, Glavic Á. Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. J Cell Biol. 2020 Mar 2;219(3):e201905228. doi: 10.1083/jcb.201905228. PMID: 31940424; PMCID: PMC7055000.

van Leen EV, di Pietro F, Bellaïche Y. Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices. Curr Opin Cell Biol. 2020 Feb;62:9-16. doi: 10.1016/j.ceb.2019.07.013. Epub 2019 Sep 8. PMID: 31509787.

Krndija D, El Marjou F, Guirao B, Richon S, Leroy O, Bellaiche Y, Hannezo E, Matic Vignjevic D. Active cell migration is critical for steady-state epithelial turnover in the gut. Science. 2019 Aug 16;365(6454):705-710. doi: 10.1126/science.aau3429. PMID: 31416964.

Goshima G, Bellaïche Y. Editorial overview: Cell division - from molecules to tissues. Curr Opin Cell Biol. 2019 Oct;60:iii-v. doi: 10.1016/j.ceb.2019.06.006. Epub 2019 Jul 26. PMID: 31352995.

Pinheiro D, Bellaïche Y. Mechanical Force-Driven Adherens Junction Remodeling and Epithelial Dynamics. Dev Cell. 2018 Oct 8;47(1):3-19. doi: 10.1016/j.devcel.2018.09.014. Erratum in: Dev Cell. 2018 Nov 5;47(3):391. PMID: 30300588.

Edwards SS, Delgado MG, Nader GPF, Piel M, Bellaïche Y, Lennon-Duménil AM, Glavic Á. An in vitro method for studying subcellular rearrangements during cell polarization in Drosophila melanogaster hemocytes. Mech Dev. 2018 Dec;154:277-286. doi: 10.1016/j.mod.2018.08.003. Epub 2018 Aug 7. PMID: 30096416.

di Pietro F, Bellaïche Y. Actin Network Discussion during Mitotic Pseudo-Furrowing. Dev Cell. 2018 Jun 4;45(5):539-541. doi: 10.1016/j.devcel.2018.05.018. PMID: 29870713.

Bosveld F, Wang Z, Bellaïche Y. Tricellular junctions: a hot corner of epithelial biology. Curr Opin Cell Biol. 2018 Oct;54:80-88. doi: 10.1016/j.ceb.2018.05.002. Epub 2018 May 26. PMID: 29843079.

Wang Z, Bosveld F, Bellaïche Y. Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis. J Cell Sci. 2018 Jun 11;131(11):jcs215764. doi: 10.1242/jcs.215764. PMID: 29739875.

Bosveld F, Ainslie A, Bellaïche Y. Sequential activities of Dynein, Mud and Asp in centrosome-spindle coupling maintain centrosome number upon mitosis. J Cell Sci. 2017 Oct 15;130(20):3557-3567. doi: 10.1242/jcs.201350. Epub 2017 Sep 1. PMID: 28864767.

Guirao B, Bellaïche Y. Biomechanics of cell rearrangements in Drosophila. Curr Opin Cell Biol. 2017 Oct;48:113-124. doi: 10.1016/j.ceb.2017.06.004. Epub 2017 Jul 18. PMID: 28732313.

Tissot N, Lepesant JA, Bernard F, Legent K, Bosveld F, Martin C, Faklaris O, Bellaïche Y, Coppey M, Guichet A. Distinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyte. Nat Commun. 2017 Apr 27;8:15168. doi: 10.1038/ncomms15168. PMID: 28447612; PMCID: PMC5414183.

Park S, Gonzalez DG, Guirao B, Boucher JD, Cockburn K, Marsh ED, Mesa KR, Brown S, Rompolas P, Haberman AM, Bellaïche Y, Greco V. Erratum: Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat Cell Biol. 2017 Mar 31;19(4):407. doi: 10.1038/ncb3503. Erratum for: Nat Cell Biol. 2017 Mar 01;19(2):155-163. PMID: 28361941.

Pinheiro D, Hannezo E, Herszterg S, Bosveld F, Gaugue I, Balakireva M, Wang Z, Cristo I, Rigaud SU, Markova O, Bellaïche Y. Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows. Nature. 2017 May 4;545(7652):103-107. doi: 10.1038/nature22041. Epub 2017 Mar 15. PMID: 28296858; PMCID: PMC6143170.

Park S, Gonzalez DG, Guirao B, Boucher JD, Cockburn K, Marsh ED, Mesa KR, Brown S, Rompolas P, Haberman AM, Bellaïche Y, Greco V. Tissue-scale coordination of cellular behaviour promotes epidermal wound repair in live mice. Nat Cell Biol. 2017 Mar 1;19(2):155-163. doi: 10.1038/ncb3472. Epub ahead of print. Erratum in: Nat Cell Biol. 2017 Mar 31;19(4):407. PMID: 28248302; PMCID: PMC5581297.

Bellaïche Y. Cell Division in the Light of Modeling. Dev Cell. 2016 Sep 26;38(6):584-6. doi: 10.1016/j.devcel.2016.09.008. PMID: 27676430.

Bosveld F, Markova O, Guirao B, Martin C, Wang Z, Pierre A, Balakireva M, Gaugue I, Ainslie A, Christophorou N, Lubensky DK, Minc N, Bellaïche Y. Epithelial tricellular junctions act as interphase cell shape sensors to orient mitosis. Nature. 2016 Feb 25;530(7591):495-8. doi: 10.1038/nature16970. Epub 2016 Feb 17. Erratum in: Nature. 2016 Jun 2;534(7605):138. PMID: 26886796; PMCID: PMC5450930.

Bosveld F, Guirao B, Wang Z, Rivière M, Bonnet I, Graner F, Bellaïche Y. Modulation of junction tension by tumor suppressors and proto-oncogenes regulates cell-cell contacts. Development. 2016 Feb 15;143(4):623-34. doi: 10.1242/dev.127993. Epub 2016 Jan 25. PMID: 26811379.

Guirao B, Rigaud SU, Bosveld F, Bailles A, López-Gay J, Ishihara S, Sugimura K, Graner F, Bellaïche Y. Unified quantitative characterization of epithelial tissue development. Elife. 2015 Dec 12;4:e08519. doi: 10.7554/eLife.08519. PMID: 26653285; PMCID: PMC4811803.

Martín-Bermudo MD, Bardet PL, Bellaïche Y, Malartre M. The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development. Development. 2015 Apr 15;142(8):1492-501. doi: 10.1242/dev.110585. Epub 2015 Mar 26. PMID: 25813543.

Pinheiro D, Bellaïche Y. Making the most of the midbody remnant: specification of the dorsal-ventral axis. Dev Cell. 2014 Feb 10;28(3):219-20. doi: 10.1016/j.devcel.2014.01.026. PMID: 24525182.

Bouissou A, Vérollet C, de Forges H, Haren L, Bellaïche Y, Perez F, Merdes A, Raynaud-Messina B. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. EMBO J. 2014 Jan 13;33(2):114-28. doi: 10.1002/embj.201385967. PMID: 24421324; PMCID: PMC3989606.

Herszterg S, Pinheiro D, Bellaïche Y. A multicellular view of cytokinesis in epithelial tissue. Trends Cell Biol. 2014 May;24(5):285-93. doi: 10.1016/j.tcb.2013.11.009. Epub 2013 Dec 28. PMID: 24380642.

Bellaiche Y. Yohanns Bellaiche: Mastering multiscale morphology. Interview by Caitlin Sedwick. J Cell Biol. 2013 Oct 14;203(1):4-5. doi: 10.1083/jcb.2031pi. PMID: 24127211; PMCID: PMC3798242.

Sugimura K, Bellaïche Y, Graner F, Marcq P, Ishihara S. Robustness of force and stress inference in an epithelial tissue. Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:2712-5. doi: 10.1109/EMBC.2013.6610100. PMID: 24110287.

Degoutin JL, Milton CC, Yu E, Tipping M, Bosveld F, Yang L, Bellaiche Y, Veraksa A, Harvey KF. Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous. Nat Cell Biol. 2013 Oct;15(10):1176-85. doi:
10.1038/ncb2829. Epub 2013 Aug 18. PMID: 23955303; PMCID: PMC4157670.

Jauffred B, Llense F, Sommer B, Wang Z, Martin C, Bellaiche Y. Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division. Development. 2013 Jul;140(13):2657-68. doi: 10.1242/dev.087338. Epub 2013 May 29. PMID: 23720047.

Bardet PL, Guirao B, Paoletti C, Serman F, Léopold V, Bosveld F, Goya Y, Mirouse V, Graner F, Bellaïche Y. PTEN controls junction lengthening and stability during cell rearrangement in epithelial tissue. Dev Cell. 2013 Jun 10;25(5):534-46. doi: 10.1016/j.devcel.2013.04.020. Epub 2013 May 23. PMID: 23707736.

Heisenberg CP, Bellaïche Y. Forces in tissue morphogenesis and patterning. Cell. 2013 May 23;153(5):948-62. doi: 10.1016/j.cell.2013.05.008. PMID: 23706734.

Herszterg S, Leibfried A, Bosveld F, Martin C, Bellaiche Y. Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue. Dev Cell. 2013 Feb 11;24(3):256-70. doi: 10.1016/j.devcel.2012.11.019. PMID: 23410940.

Bonnet I, Marcq P, Bosveld F, Fetler L, Bellaïche Y, Graner F. Mechanical state, material properties and continuous description of an epithelial tissue. J R Soc Interface. 2012 Oct 7;9(75):2614-23. doi: 10.1098/rsif.2012.0263. Epub 2012 May 23. PMID: 22628216; PMCID: PMC3427523.

Bosveld F, Bonnet I, Guirao B, Tlili S, Wang Z, Petitalot A, Marchand R, Bardet PL, Marcq P, Graner F, Bellaïche Y. Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway. Science. 2012 May 11;336(6082):724-7. doi: 10.1126/science.1221071. Epub 2012 Apr 12. PMID: 22499807.

Bellaïche Y, Bosveld F, Graner F, Mikula K, Remesíková M, Smísek M. New robust algorithm for tracking cells in videos of Drosophila morphogenesis based on finding an ideal path in segmented spatio-temporal cellular structures. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:6609-12. doi: 10.1109/IEMBS.2011.6091630. PMID: 22255854.

Jauffred B, Bellaiche Y. Analyzing frizzled signaling using fixed and live imaging of the asymmetric cell division of the Drosophila sensory organ precursor cell. Methods Mol Biol. 2012;839:19-25. doi: 10.1007/978-1-61779-510-7_2. PMID: 22218889.

Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM. Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation. Immunity. 2011 Sep 23;35(3):361-74. doi: 10.1016/j.immuni.2011.07.008. Epub 2011 Aug 4. PMID: 21820334.

Morin X, Bellaïche Y. Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Dev Cell. 2011 Jul 19;21(1):102-19. doi: 10.1016/j.devcel.2011.06.012. PMID: 21763612.

Ségalen M, Johnston CA, Martin CA, Dumortier JG, Prehoda KE, David NB, Doe CQ, Bellaïche Y. The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Dev Cell. 2010 Nov 16;19(5):740-52. doi: 10.1016/j.devcel.2010.10.004. PMID: 21074723; PMCID: PMC3008569.

Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S. Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis. Neuron. 2010 Aug 12;67(3):392-406. doi: 10.1016/j.neuron.2010.06.027. PMID: 20696378.

Segalen M, Bellaïche Y. Cell division orientation and planar cell polarity pathways. Semin Cell Dev Biol. 2009 Oct;20(8):972-7. doi: 10.1016/j.semcdb.2009.03.018. Epub 2009 Apr 7. PMID: 19447051.

Fichelson P, Moch C, Ivanovitch K, Martin C, Sidor CM, Lepesant JA, Bellaiche Y, Huynh JR. Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in Drosophila. Nat Cell Biol. 2009 Jun;11(6):685-93. doi: 10.1038/ncb1874. Epub 2009 May 10. PMID: 19430468.

Bellaïche Y, Munro E. Pushing the frontiers of development. Development. 2009 Jan;136(2):173-7. doi: 10.1242/dev.028407. PMID: 19103801.

Leibfried A, Fricke R, Morgan MJ, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol. 2008 Nov 11;18(21):1639-48. doi: 10.1016/j.cub.2008.09.063. Epub 2008 Oct 30. PMID: 18976911.

Leibfried A, Bellaïche Y. Functions of endosomal trafficking in Drosophila epithelial cells. Curr Opin Cell Biol. 2007 Aug;19(4):446-52. doi: 10.1016/j.ceb.2007.06.004. Epub 2007 Jul 24. PMID: 17651956.

Balakireva M, Rossé C, Langevin J, Chien YC, Gho M, Gonzy-Treboul G, Voegeling-Lemaire S, Aresta S, Lepesant JA, Bellaiche Y, White M, Camonis J. The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol. 2006 Dec;26(23):8953-63. doi: 10.1128/MCB.00506-06. Epub 2006 Sep 25. PMID: 17000765; PMCID: PMC1636832.

Courty S, Luccardini C, Bellaiche Y, Cappello G, Dahan M. Tracking individual kinesin motors in living cells using single quantum-dot imaging. Nano Lett. 2006 Jul;6(7):1491-5. doi: 10.1021/nl060921t. PMID: 16834436.

Ségalen M, David N, Bellaïche Y. Les protéines G hétérotrimériques au cours de la division asymétrique chez la drosophile [The heterotrimeric G proteins during asymmetric cell division in Drosophila]. Med Sci (Paris). 2006 Mar;22(3):243-6. French. doi: 10.1051/medsci/2006223243. PMID: 16527201.

Bellaiche Y, Gotta M. Heterotrimeric G proteins and regulation of size asymmetry during cell division. Curr Opin Cell Biol. 2005 Dec;17(6):658-63. doi: 10.1016/j.ceb.2005.10.002. Epub 2005 Oct 21. PMID: 16243504.

David NB, Martin CA, Segalen M, Rosenfeld F, Schweisguth F, Bellaïche Y. Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division. Nat Cell Biol. 2005 Nov;7(11):1083-90. doi: 10.1038/ncb1319. PMID: 16228010.

Langevin J, Morgan MJ, Sibarita JB, Aresta S, Murthy M, Schwarz T, Camonis J, Bellaïche Y. Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane. Dev Cell. 2005 Sep;9(3):365-76. doi: 10.1016/j.devcel.2005.07.013. PMID: 16224820.

Langevin J, Le Borgne R, Rosenfeld F, Gho M, Schweisguth F, Bellaïche Y. Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells. Curr Biol. 2005 May 24;15(10):955-62. doi: 10.1016/j.cub.2005.04.054. PMID: 15916953.

Formstecher E, Aresta S, Collura V, Hamburger A, Meil A, Trehin A, Reverdy C, Betin V, Maire S, Brun C, Jacq B, Arpin M, Bellaiche Y, Bellusci S, Benaroch P, Bornens M, Chanet R, Chavrier P, Delattre O, Doye V, Fehon R, Faye G, Galli T, Girault JA, Goud B, de Gunzburg J, Johannes L, Junier MP, Mirouse V, Mukherjee A, Papadopoulo D, Perez F, Plessis A, Rossé C, Saule S, Stoppa-Lyonnet D, Vincent A, White M, Legrain P, Wojcik J, Camonis J, Daviet L. Protein interaction mapping: a Drosophila case study. Genome Res. 2005 Mar;15(3):376-84. doi: 10.1101/gr.2659105. Epub 2005 Feb 14. PMID: 15710747; PMCID: PMC551564.

Zeidler MP, Tan C, Bellaiche Y, Cherry S, Häder S, Gayko U, Perrimon N. Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol. 2004 Jul;22(7):871-6. doi: 10.1038/nbt979. Epub 2004 Jun 6. PMID: 15184905.

Audebert S, Navarro C, Nourry C, Chasserot-Golaz S, Lécine P, Bellaiche Y, Dupont JL, Premont RT, Sempéré C, Strub JM, Van Dorsselaer A, Vitale N, Borg JP. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. Curr Biol. 2004 Jun 8;14(11):987-95. doi: 10.1016/j.cub.2004.05.051. PMID: 15182672.

Orgogozo V, Schweisguth F, Bellaïche Y. Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila. Mech Dev. 2004 May;121(5):427-36. doi: 10.1016/j.mod.2004.04.001. PMID: 15147761.

Bellaïche Y, Beaudoin-Massiani O, Stuttem I, Schweisguth F. The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila. Development. 2004 Jan;131(2):469-78. doi: 10.1242/dev.00928. PMID: 14701683.