Contributions
2024 - The AsiDNA™ decoy mimicking DSBs protects the normal tissue from radiation toxicity through a DNA-PK/p53/p21-dependent G1/S arrest. Sesink A, Becerra M, Ruan JL, Leboucher S, Dubail M, Heinrich S, Jdey W, Petersson K, Fouillade C, Berthault N, Dutreix M, Girard PM. NAR Cancer. 2024 Mar 12;6(1):zcae011.
2023 - Degradable polyisoprene by radical ring-opening polymerization and application to polymer prodrug nanoparticles. Lages, M., Pesenti, T., Zhu, C., Le, D., Mougin, J., Guillaneuf, Y. and Nicolas, J., 2023. Chemical Science, 14(12), pp.3311-3325.
2023 - Replication gap suppression depends on the double-strand DNA binding activity of BRCA2. Vugic D, Dumoulin I, Martin C, Minello A, Alvaro-Aranda L, Gomez-Escudero J, Chaaban R, Lebdy R, von Nicolai C, Boucherit V, Ribeyre C, Constantinou A, Carreira A. Nat Commun. 2023 Jan 27;14(1):446.
2023 - Tubulin polyglutamylation differentially regulates microtubule‐interacting proteins. Mariya Genova, Lenka Grycova, Verena Puttrich, Maria M Magiera, Zdenek Lansky, Carsten Janke, Marcus Braun. The EMBO Journal, 10.15252/embj.2022112101, 42, 5, (2023)
2023 - Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity. Dubail, M.; Heinrich, S.; Portier, L.; Bastian, J.; Giuliano, L.; Aggar, L.; Berthault, N.; Londoño-Vallejo, J.-A.; Vilalta, M.; Boivin, G.; et al. Cells 2023, 12, 2435
2023 - An interactive murine single-cell atlas of the lung responses to radiation injury. Curras-Alonso S, Soulier J, Defard T, Weber C, Heinrich S, Laporte H, Leboucher S, Lameiras S, Dutreix M, Favaudon V, Massip F, Walter T, Mueller F, Londoño-Vallejo JA, Fouillade C. Nat Commun. 2023 Apr 28;14(1):2445.
2023 - 53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication. Melissa Leriche, Clara Bonnet, Jagannath Jana, Gita Chhetri, Sabrina Mennour, Sylvain Martineau, Vincent Pennaneach, Didier Busso, Xavier Veaute, Pascale Bertrand, Sarah Lambert, Kumar Somyajit, Patricia Uguen, Stéphan Vagner. Cell Reports, Volume 42, Issue 11, 2023, 113412, ISSN 2211-1247.
2023 - Anti-Cancer and Radio-Sensitizing Properties of New Bimetallic (<i>N</i>-Heterocyclic Carbene)-Amine-Pt(II) Complexes. Tao Jia, Oumar Diane, Deepanjan Ghosh, Myriem Skander, Gaelle Fontaine, Pascal Retailleau, Joël Poupon, Jérôme Bignon, Ytabelle Maga Moulai Siasia, Vincent Servajean, Nathalie Hue, Jean-François Betzer, Angela Marinetti, Sophie Bombard. Journal of Medicinal Chemistry, (2023 mai 16)
2023 - Ultrabright two-photon excitable red-emissive fluorogenic probes for fast and wash-free bioorthogonal labelling in live cells. Auvray M, Naud-Martin D, Fontaine G, Bolze F, Clavier G, Mahuteau-Betzer F. Chem Sci. 2023 Jul 4;14(30):8119-8128.
2022 - Photo-triggerable liposomes based on lipid-porphyrin conjugate and cholesterol combination: Formulation and mechanistic study on monolayers and bilayers. Massiot, J., Abuillan, W., Konovalov, O. and Makky, A., 2022. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1864(1), p.183812.
2022 - Degradable vinyl copolymer nanoparticles/latexes by aqueous nitroxide-mediated polymerization-induced self-assembly. Lages, M., Gil, N., Galanopoulo, P., Mougin, J., Lefay, C., Guillaneuf, Y., Lansalot, M., D’agosto, F. and Nicolas, J., 2022. Macromolecules, 55(21), pp.9790-9801.
2022 - PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma. Sittewelle M, Kappès V, Zhou C, Lécuyer D, Monsoro-Burq AH. Life Sci Alliance. 2022 Aug 1;5(12):e202201377.
2022 - Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation. Silina L, Dufour F, Rapinat A, Reyes C, Gentien D, Maksut F, Radvanyi F, Verrelle P, Bernard-Pierrot I, Mégnin-Chanet F. Int J Mol Sci. 2022 Aug 4;23(15):8671.
2022 - Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma. Maïlys Rossi, Julie Talbot, Patricia Piris, Marion Le Grand, Marie-Pierre Montero, et al. EBioMedicine, 2022, 82 (7), pp.104149.
2022 - R. Mougeot, S. Oger, M. Auvray, T. Gallavardin, S. Leleu, F. Mahuteau-Betzer, X. Franck, Eur. J. Org. Chem. 2022, e202101397.
2022 - Cellular Detection of a Mitochondria Targeted Brominated Vinyl Triphenylamine Optical Probe (TP-Br) by X-Ray Fluorescence Microscopy. Nagarajan S, Poyer F, Fourmois L, Naud-Martin D, Medjoubi K, Somogyi A, Schanne G, Henry L, Delsuc N, Policar C, Bertrand HC, Mahuteau-Betzer F. Chemistry. 2022 Mar 10;28(15):e202104424.
2022 - Acridine-O6-benzylguanine hybrids: Synthesis, DNA binding, MGMT inhibition and antiproliferative activity. Franco Pinto J, Fillion A, Duchambon P, Bombard S, Granzhan A. Eur J Med Chem. 2022 Jan 5;227:113909.
2022 - Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA. Berthault, N.; Bergam, P.; Pereira, F.; Girard, P.-M.; Dutreix, M. Cells 2022, 11, 2149
2022 - The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors. Bartl, J., Zanini, M., Bernardi, F. et al. Nat Commun 13, 4061 (2022).
2022 - On the Road Toward More Efficient Biocompatible Two-Photon Excitable Fluorophores. Auvray M, Bolze F, Naud-Martin D, Poulain M, Bossuat M, Clavier G, Mahuteau-Betzer F. Chemistry. 2022 Mar 7;28(14):e202104378.
2021 - Synthesis and supramolecular arrangement of new stearoyl acid-based phenalenone derivatives. Godard, J., Chapron, D., Bregier, F., Rosilio, V. and Sol, V., 2021. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 612, p.125988
2021 - Gemcitabine lipid prodrugs: the key role of the lipid moiety on the self-assembly into nanoparticles. Coppens, E., Desmaële, D., Mougin, J., Tusseau-Nenez, S., Couvreur, P. and Mura, S., 2021. Chemistry, 32(4), pp.782-793
2021 - Gemcitabine lipid prodrug nanoparticles: Switching the lipid moiety and changing the fate in the bloodstream. Coppens, E., Desmaële, D., Naret, T., Garcia-Argote, S., Feuillastre, S., Pieters, G., Cailleau, C., Paul, J.L., Prost, B., Solgadi, A. and Michel, J.P., 2021. International Journal of Pharmaceutics, 609, p.121076.
2021 - BrdU immuno-tagged G-quadruplex ligands: a new ligand-guided immunofluorescence approach for tracking G-quadruplexes in cells. Thibaut Masson, Corinne Landras Guetta, Eugénie Laigre, Anne Cucchiarini, Patricia Duchambon, Marie-Paule Teulade-Fichou, Daniela Verga. Nucleic Acids Research, Volume 49, Issue 22, 16 December 2021, Pages 12644–12660,
2021 - BMP Signaling Is Enhanced Intracellularly by FHL3 Controlling WNT-Dependent Spatiotemporal Emergence of the Neural Crest. Alkobtawi, Mansour, Patrick Pla, et Anne H. Monsoro-Burq. Cell Reports 35, no 12 (22 juin 2021): 109289.
2021 - BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair. Sessa G, Gómez-González B, Silva S, Pérez-Calero C, Beaurepere R, Barroso S, Martineau S, Martin C, Ehlén Å, Martínez JS, Lombard B, Loew D, Vagner S, Aguilera A, Carreira A. EMBO J. 2021 Apr 1;40(7):e106018.
2021 - Rrp1 translocase and ubiquitin ligase activities restrict the genome destabilising effects of Rad51 in fission yeast. Muraszko J, Kramarz K, Argunhan B, Ito K, Baranowska G, Kurokawa Y, Murayama Y, Tsubouchi H, Lambert S, Iwasaki H, Dziadkowiec D. Nucleic Acids Res. 2021 Jul 9;49(12):6832-6848.
2021 - BRN2 is a non-canonical melanoma tumor-suppressor. Hamm, M., Sohier, P., Petit, V. et al. Nat Commun 12, 3707 (2021).
2021 - Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. Gadadhar S, Alvarez Viar G, Hansen JN, Gong A, Kostarev A, Ialy-Radio C, Leboucher S, Whitfield M, Ziyyat A, Touré A, Alvarez L, Pigino G, Janke C. Science. 2021 Jan 8;371(6525):pii: eabd4914.
2021 - Modulation of cellular fate of vinyl triarylamines through structural fine tuning: to stay or not to stay in the mitochondria? Laura Fourmois, Florent Poyer, Aude Sourdon, Delphine Naud-Martin, Sounderya Nagarajan, et al. ChemBioChem, 2021, 22 (14), pp.2457-2467.
2021 - Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, Yuan X, Genova M, Gadadhar S, Leboucher S, Birling MC, Klein D, Martini R, Janke C, Magiera MM. EMBO J. 2021 Sep 1;40(17):e108498.
2021 - Silafluorene as a promising core for cell-permeant, highly bright and two-photon excitable fluorescent probes for live-cell imaging. Marie Auvray, Frederic Bolze, Gilles Clavier, Florence Mahuteau-Betzer. Dyes and Pigments 187 (2021) 109083
2021 - A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Aktary, Z., Conde-Perez, A., Rambow, F. et al. Commun Biol 4, 423 (2021).
2020 - Assessment of various formulation approaches for the application of beta-lapachone in prostate cancer therapy. Wu, X., Kasselouri, A., Vergnaud-Gauduchon, J. and Rosilio, V., 2020. International journal of pharmaceutics, 579, p.119168.
2020 - Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy. Zmerli, I., Michel, J.P. and Makky, A., 2020. Journal of Materials Chemistry B, 8(20), pp.4489-4504
2020 - Green one-step synthesis of medical nanoagents for advanced radiation therapy. Salado-Leza, D., Porcel, E., Yang, X., Štefančíková, L., Bolsa-Ferruz, M., Savina, F., Dragoe, D., Guerquin-Kern, J.L., Wu, T.D., Hirayama, R. and Remita, H., 2020. Nanotechnology, science and applications, pp.61-76
2020 - AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models. Clin Cancer Res. Ferreira S, Foray C, Gatto A, Larcher M, Heinrich S, Lupu M, Mispelter J, Boussin FD, Pouponnot C, Dutreix M. Clin Cancer Res. 2020 Nov 1;26(21):5735-5746.
2020 - The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal. Kramarz, K., Schirmeisen, K., Boucherit, V. et al. Nat Commun 11, 5643 (2020).
2020 - FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence. Fouillade C, Curras-Alonso S, Giuranno L, Quelennec E, Heinrich S, Bonnet-Boissinot S, Beddok A, Leboucher S, Karakurt HU, Bohec M, Baulande S, Vooijs M, Verrelle P, Dutreix M, Londoño-Vallejo A, Favaudon V. Clin Cancer Res. 2020 Mar 15;26(6):1497-1506.
2020 - Targeted Knockout of b-Catenin in Adult Melanocyte Stem Cells Using a Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects. Madeleine Le Coz, Zackie Aktary, Nisamanee Charoenchon, Takahiro Kunisada, and Lionel Larue. Journal of Investigative Dermatology (2020) doi:10.1016/j.jid.2020.08.025
2020 - Topoisomerase IIα prevents ultrafine anaphase bridges by two mechanisms. Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Gaëlle Fontaine, Sarah Lambert and Mounira Amor-Guéret. Open Biol. 10:190259
2020 - Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1. Ehlén Å, Martin C, Miron S, Julien M, Theillet FX, Ropars V, Sessa G, Beaurepere R, Boucherit V, Duchambon P, El Marjou A, Zinn-Justin S, Carreira A. Nat Commun. 2020 Apr 14;11(1):1819.
2020 - A decrease in NAMPT activity impairs basal PARP‑1 activity in cytidine deaminase deficient‑cells, independently of NAD+. Sandra Cunha Silveira, Géraldine Buhagiar‑Labarchède, Rosine Onclercq‑Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton & Mounira Amor‑Guéret. Nature (2020) 10:13907
2020 - Tubulin polyglutamylation is a general traffic-control mechanism in hippocampal neurons. Bodakuntla S, Schnitzler A, Villablanca C, Gonzalez-Billault C, Bieche I, Janke C, Magiera MM. J Cell Sci 133: jcs241802
2020 - Measuring the Impact of Tubulin Posttranslational Modifications on Axonal Transport. Bodakuntla S, Magiera MM, Janke C. Methods Mol Biol 2101: 353-370
2020 - Knocking Out Multiple Genes in Cultured Primary Neurons to Study Tubulin Posttranslational Modifications. Bodakuntla S, Janke C, Magiera MM. Methods Mol Biol 2101: 327-351
2019 - An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma. Morgane Morabito, Magalie Larcher, Florence MG Cavalli, Chloé Foray, Antoine Forget, Liliana Mirabal-Ortega, Mamy Andrianteranagna, Sabine Druillennec, Alexandra Garancher, Julien Masliah-Planchon, Sophie Leboucher, Abel Debalkew, Alessandro Raso, Olivier Delattre, Stéphanie Puget, François Doz, Michael D Taylor, Olivier Ayrault, Franck Bourdeaut, Alain Eychène, Celio Pouponnot. EMBO Molecular Medicine 11, no 8 (1 août 2019): e9830.