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Unité
ANGELA TADDEI / NATHALIE DOSTATNI
Dynamique du noyau (UMR3664)

Les équipes de cette unité s’intéressent aux relations entre information génétique et épigénétique au cours du développement, lors de la mise en place des destins cellulaires propres à chaque lignée de l’organisme. Il s’agit aussi de comprendre comment ces informations sont altérées en contexte pathologique comme le cancer.

Chiffres-clés
18
nationalités pour 55 personnes
6
systèmes modèles
37200
milliards de noyaux dans le corps humain
Publications clés
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Événements scientifiques
19 juin
2023
Séminaire Nuclear dynamic series
14h-15h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Atypical genome folding and gene regulation by SMC complexes in the nematode C. elegans
In the majority of species studied thus far, chromosomes are organized into topologically associated domains (TADs). TAD formation depends on between cohesin, a member of the structural maintenance of chromosome (SMC) complexes family, and boundary sequence elements recognized by transcription factors. TADs are highly conserved across different cell types or species in syntenic regions and are cru
14 juin
2023
Séminaire Nuclear dynamic series
09h-10h
Centre de recherche - Paris - Amphithéâtre Marie Curie
In time we trust: how precise temporal regulation of the genome is important for embryogenesis
How a single embryonic cell interprets its genome to give rise to the many diverse cell types that build an animal is one of nature’s enduring mysteries. Unravelling it promises to not only yield new insights into disorders of development and cancer, but also reveal the organizing principles of life. The genes that drive development each typically have many different enhancers. Properly coor
30 mai
2023
Séminaire
09h-10h
Centre de recherche - Paris - Amphithéâtre Marie Curie
The various layers regulating genomic instability in cancer
Nuclear Dynamics Extras Seminar (UMR3664) & Medico-Scientific Program in Epigenetics (Joint Event)

Genomic instability is a major driving force of tumorigenesis. Our goal is to understand the mechanisms underlying genomic instability during cancer development, with a focus on the role of oncogene and tumor suppressor-affected networks, in DNA replication stress, transcription and chromatin
17 mai
2023
Séminaire
16h-17h
Centre de recherche - Paris - Amphithéâtre Marie Curie
The three-dimensional architecture of the human genome: understanding the physical mechanisms controlling gene expression
In vivo, the human genome folds into a characteristic ensemble of 3D structures. The mechanism driving the folding process remains unknown. A theoretical model for chromatin (the minimal chromatin model) explains the folding of interphase chromosomes and generates chromosome

conformations consistent with experimental data is presented. The energy landscape of the model was derived by using the
16 mai
2023
Séminaire
14h-15h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Epigenetic factor competition can reshape the EMT landscape in breast cancer cells
We are nearing the tenth anniversary of the first papers applying methods of computational systems biology to the study of the epithelial-mesenchymal transition (EMT) and its relevance to cancer metastasis. This undertaking has been a major success, leading to a much-improved understanding of EMT itself and its connection to tumor initiation and drug resistance. But of course, new questions have a
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