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Unité
PASCAL HERSEN / MATHIEU COPPEY
Physique des Cellules et Cancer (UMR168)

Le laboratoire Physico Chimie Curie, pionnier de l’interface entre la physique, la chimie et la biologie, depuis sa création en 1996, est un laboratoire de recherche interdisciplinaire explorant le rôle des lois physiques dans l’architecture et les fonctions des systèmes cellulaires.

Chiffres-clés
150
physiciens, chimistes et biologistes dont 35 chercheurs, 39 doctorants, 31 postdoctorants et 28 techniciens et ingénieurs
13
Equipes de recherche labelisées par les grandes agences de financements (ERC, ANR, H2020, FRM, ARC, La Ligue, etc…)
4
plateaux techniques en biochimie et biologie moléculaire, microfluidique, microfabrication, microscopie électronique
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Événements scientifiques
17 Juil
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Bioengineering Human Embryo and Organ Models
Early human development remains mysterious and difficult to study.  Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids).  The controllability and reproducibility of these human development models, coupled with the ea
7 juin
2024
Séminaire
15h-23h
Centre de recherche - Paris - Amphithéâtre IPGG - 6 rue Jean Calvin, Paris 5e
Active nematic order in morphogenesis of the Hydra
Hydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces the regeneration of viable, two headed animals. Topological defects in the supracellular nematic organization of actin were previously correlated with the new head
29 mai
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Learning dynamical models from stochastic trajectories
The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experimental trajectories reflecting these dynamical laws. Inferring physical models from imperfect experimenta
24 avr
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
High-speed imaging of droplet and vesicle formation during emulsion transfer (cDICE)
Giant unilamellar vesicles (GUVs) are widely used as in vitro model membranes in biophysics and as cell-sized containers in synthetic biology. Despite their ubiquitous use, there is no one-size-fits-all method for their production. Numerous methods have been developed to meet the demanding requirements of reproducibility, reliability, and high yield, while simultaneously achieving robust encapsula
17 avr
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
The Countoscope: Measuring Dynamics by Counting Particles in Boxes
Any imaging technique is limited by lts field of view. As objects or particles move in and out of the observation field, tracking their motion, especially over long periods, beoomes challenging. ln addition, available analysis techniques face challenges reconstructing trajectories in dense and heterogeneous systems where accurately labelling partlcles is difficult. Here, we shift this paradigm by
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