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PASCAL HERSEN / MATHIEU COPPEY
Physico-chimie Curie (UMR168)

Le laboratoire Physico Chimie Curie, pionnier de l’interface entre la physique, la chimie et la biologie, depuis sa création en 1996, est un laboratoire de recherche interdisciplinaire explorant le rôle des lois physiques dans l’architecture et les fonctions des systèmes cellulaires.

Chiffres-clés
150
physiciens, chimistes et biologistes dont 35 chercheurs, 39 doctorants, 31 postdoctorants et 28 techniciens et ingénieurs
13
Equipes de recherche labelisées par les grandes agences de financements (ERC, ANR, H2020, FRM, ARC, La Ligue, etc…)
4
plateaux techniques en biochimie et biologie moléculaire, microfluidique, microfabrication, microscopie électronique
Publications clés
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Actualités
  • cancer sous pression
    Le cancer sous pression
    Une équipe de chercheurs de l’Institut Curie a exploré en profondeur les mécanismes liant pression mécanique et cancérogenèse. Ils ont découvert une protéine-clé, potentielle cible thérapeutique contre de nombreux cancers. Ces travaux sont publiés dans Communications Biology.
    17/02/2022
  • Portrait Valentina Emiliani
    Prix Maxime Dahan 2021
    Lors du 2e symposium organisé à l’Institut Curie en hommage à Maxime Dahan, le prix Maxime Dahan 2021 pour l’Instrumentation et les Méthodes Innovantes à l’Interface Physique-Biologie-Médecine a été décerné à Valentina Emiliani, directrice de recherche CNRS à l'Institut de la Vision de Paris.
    04/02/2022
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Événements scientifiques
18 mai
2022
Séminaire Physico-Chimie
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Dynamic remodelling of the microtubule cytoskeleton throughout mitosis
As the nuclear envelop breaks down, microtubules and motors self-assemble into the mitotic spindle, a dynamic structure essential to congress and biorient chromosomes before partitioning of sister chromatids to the daughter cells in anaphase. Microtubules are dynamically reorganized and regulated throughout mitosis to ensure faithful chromosome segregation. Mitotic kinase activity is also key to p
20 avr
2022
Séminaire Physico-Chimie
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
The inner life of adhesion sites: deciphering the molecular ballet in integrin-based adhesions
Integrin-based focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Super-resolution microscopy revealed that FAs are organized at the nanoscale into functional layers from the lower plasma membrane to the upper actin cytoskeleton. Among the main partners of integrin adhesion receptors, talin and kindlin are two ess
13 avr
2022
Séminaire Physico-Chimie
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Chromatin as a biomolecular condensate
Cells package their genomic DNA into a complex with proteins called chromatin. Chromatin is partitioned into subcompartments that differ from each other with respect to their compaction, molecular composition and biological function. One example are the micron-sized spherical heterochromatin foci that are present in several differentiated cell types and that are readily visible under the microscop
7 avr
2022
Séminaire Physico-Chimie
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Size scaling from cells to organisms
Appropriate size of the body and its parts is crucial for organismal function. For example, small discrepancies in limb length severely obstruct motility, and overgrowth of cardiac muscle is a prevalent cause of heart failure. Faithful development must therefore involve mechanisms that ensure correct body size, and that coordinate the growth of different cells and organs.
We combine theory and qu
6 avr
2022
Séminaire Physico-Chimie
11h-12h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Curvature-Dependent Self-Organization in Cellular Systems
The plasma membrane is continuously deformed inwardly and outwardly by a wide range of intracellular and intercellular forces. In response to such nanoscale deformations, curvature-sensitive signaling molecules enrich at these curved membrane sites. Strikingly, some of the recruited molecules not only sense but also modify forces at the PM, forming self-organizing circuits at curved cellular membr
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