Le laboratoire Physico Chimie Curie, pionnier de l’interface entre la physique, la chimie et la biologie, depuis sa création en 1996, est un laboratoire de recherche interdisciplinaire explorant le rôle des lois physiques dans l’architecture et les fonctions des systèmes cellulaires.

Chiffres-clés
150
physiciens, chimistes et biologistes dont 35 chercheurs, 39 doctorants, 31 postdoctorants et 28 techniciens et ingénieurs
13
Equipes de recherche labelisées par les grandes agences de financements (ERC, ANR, H2020, FRM, ARC, La Ligue, etc…)
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plateaux techniques en biochimie et biologie moléculaire, microfluidique, microfabrication, microscopie électronique
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Événements scientifiques
24 avr
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
High-speed imaging of droplet and vesicle formation during emulsion transfer (cDICE)
Giant unilamellar vesicles (GUVs) are widely used as in vitro model membranes in biophysics and as cell-sized containers in synthetic biology. Despite their ubiquitous use, there is no one-size-fits-all method for their production. Numerous methods have been developed to meet the demanding requirements of reproducibility, reliability, and high yield, while simultaneously achieving robust encapsula
17 avr
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
The Countoscope: Measuring Dynamics by Counting Particles in Boxes
Any imaging technique is limited by lts field of view. As objects or particles move in and out of the observation field, tracking their motion, especially over long periods, beoomes challenging. ln addition, available analysis techniques face challenges reconstructing trajectories in dense and heterogeneous systems where accurately labelling partlcles is difficult. Here, we shift this paradigm by
3 avr
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Mechanisms of Organelle Remodeling for Cellular Function
To function, organisms rely on vital organs which, in turn, rely on specialized cells. At the subcellular scale, cell specialization is notably driven by robust mechanisms of organelle remodeling. Thus, discovering these mechanisms is key for the fundamental understanding of organisms in health and disease, as well as for improved organ engineering. In this seminar, I will discuss my research on o
27 Mar
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Biophotonics, Robots, Ghosts
In this talk, I will discuss two qualitatively new directions in biophotonics:

i) FLUCS & interactive microscopy: We have made efforts to understand and control cellular organization through the induction of thermoviscous flows. This includes the non-invasive interference and guidance of PAR polarization in C. elegans, probe-free intracellular rheology, and recently, nanoscale manipula
20 Mar
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation
The order Corynebacteriales includes major industrial and pathogenic actinobacteria such as Corynebacterium glutamicum or Mycobacterium tuberculosis. Their elaborate multi-layered cell wall and their polar growth mode impose a stringent coordination between the septal divisome, organized around the tubulin-like protein FtsZ, and the polar elongasome, assembled around the tropomyosin-like protein W
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