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PASCAL HERSEN / MATHIEU COPPEY
Physico-chimie Curie (UMR168)

Le laboratoire Physico Chimie Curie, pionnier de l’interface entre la physique, la chimie et la biologie, depuis sa création en 1996, est un laboratoire de recherche interdisciplinaire explorant le rôle des lois physiques dans l’architecture et les fonctions des systèmes cellulaires.

Chiffres-clés
150
physiciens, chimistes et biologistes dont 35 chercheurs, 39 doctorants, 31 postdoctorants et 28 techniciens et ingénieurs
13
Equipes de recherche labelisées par les grandes agences de financements (ERC, ANR, H2020, FRM, ARC, La Ligue, etc…)
4
plateaux techniques en biochimie et biologie moléculaire, microfluidique, microfabrication, microscopie électronique
Publications clés
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Actualités
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Événements scientifiques
27 Sep
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Genetic Regulation of Developmental Timing in C. elegans
The nematode Caenorhabditis elegans is an excellent experimental system for studying how cell division and differentiation events are orchestrated in the context of a developing animal. A set of master regulatory genes, so calle ‘heterochronic genes’, have been identified in C. elegans whose activity changes as the worm progresses through larval development. The various heterochronic g
20 Sep
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Developmental robustness: growth heterogeneity at different scales and mechanical feedback
If you extend your two arms, you will likely find that they match in length by better than 0.2%, though they do not seem to directly communicate during their development and growth. Similarly, flowers in an individual plant are likely to be almost identical in size and shape. Such precision, or robustness, in organ size might seem trivial when conceptualizing observations as reflecting a ‘de
13 Sep
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Sex and Gender Bias in research: from career path to the test tube
The underrepresentation of women in science is a major concern for the scientific community,
and its causes (stereotypes, self-censorship, sexism etc) are being actively addressed in order to
guarantee equal opportunities in reaching those positions. Yet, one of the much less debated
issue is its consequence on the type of scientific knowledge we produce. Significant case studies
reveal pervas
21 juin
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Learning the statistical folding of bacterial chromosomes
The physical organization of bacterial chromosomes is inherently variable, with large conformational fluctuations both from cell to cell and over time. Yet, chromosomes must also be structured to facilitate processes such as transcription, replication, and segregation. A physical description of this dynamic statistical folding of bacteria
8 juin
2023
Séminaire
14h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Live cell force dynamics – Do cell membranes support or resist tension propagation?
Membrane tension is thought to be a long-range integrator of cell physiology, where it has been proposed to enable cell polarity during migration through front-back coordination and long-range protrusion competition. These roles necessitate effective tension transmission across the cell. However, conflicting observations have left the field divided as to whether cell membranes support or resist te
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