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PASCAL HERSEN / MATHIEU COPPEY
Physico-chimie Curie (UMR168)

Le laboratoire Physico Chimie Curie, pionnier de l’interface entre la physique, la chimie et la biologie, depuis sa création en 1996, est un laboratoire de recherche interdisciplinaire explorant le rôle des lois physiques dans l’architecture et les fonctions des systèmes cellulaires.

Chiffres-clés
150
physiciens, chimistes et biologistes dont 35 chercheurs, 39 doctorants, 31 postdoctorants et 28 techniciens et ingénieurs
13
Equipes de recherche labelisées par les grandes agences de financements (ERC, ANR, H2020, FRM, ARC, La Ligue, etc…)
4
plateaux techniques en biochimie et biologie moléculaire, microfluidique, microfabrication, microscopie électronique
Publications clés
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Actualités
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Événements scientifiques
31 mai
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Collective epigenetic processes in development and ageing
Epigenetic modifications of the DNA and chromatin, such as DNA methylation or histone modifications, underlie key processes in development, disease and ageing. Recent technological advances in single-cell genomics allow probing these epigenetic states with unprecedented molecular detail. Biological function relies, however, on the interplay between many processes in space and time and on the mesos
30 mai
2023
Séminaire
14h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Learning how closed-loop protein dynamics governs morphogenesis
Morphogenesis is the process whereby the body of an organism develops its target shape. This requires controlling complex biochemical processes that orchestrate the forces shaping large scale structure. While gene patterns and protein distributions are known to set the body axes and the coordinate-system of cell fates, less is known about the physical processes that biology harnesses to create sha
25 mai
2023
Séminaire
14h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Junctional Force Patterning drives both Positional and Orientational Order in Auditory Epithelia
For physiological function, organs must organise constituent cell types in precise spatial and orientational order. While in single-cell type epithelia, morphogenesis is driven by forces exerted at cell junctions, it is not known whether forces can drive the acquisition of patterns and polarity in organs comprising multiple cell types. In this talk, I will discuss the process of global alignment i
24 mai
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Measuring and shaping the optical phase: new tools for biology and chemistry
Spatially-resolved techniques to control and image the phase of light have deeply transformed microscopy. In this talk, I will briefly clarify the notion of optical phase and present two phase-sensitive techniques offering high sensitivity and 3D capabilities: holography and wavefront sensing. Using holography, individual magnetic nanorods can be actuated and used as probes of the local viscosity
17 mai
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Scenarios for collective dynamics in evolving tissues
Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. By focusing on the early stages of tumor evolution, I hope to enunciate scenarios for collective movements in cell dynamics and highlight their implications in understanding similar behavior in abiotic soft glassy materials. Using simulations and theory I will show that tumor c
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