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Unité
ANTONIN MORILLON / VALERIE BORDE
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Les équipes de cette unité ont pour objectif de mieux comprendre les mécanismes de maintenance de l’intégrité du génome, tels que la réplication, la réparation et la recombinaison, ainsi que le rôle des mécanismes de contrôle du cycle cellulaire et de l’expression génomique non codante dans la maintenance de l’épigénome.

 

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79
Publications depuis 2019
3
ERC depuis 2019
3
Spin-off depuis 2019
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Événements scientifiques
23 nov
2022
Séminaire
09h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Overcoming experimental and computational limitations of multiplexed imaging to study viral infections
Recent technological advances in imaging now allow to simultaneously measure dozens to

hundreds of proteins, either using successive rounds of standard IF imaging or using heavy-metal conjugated antibodies. This has enabled deep spatial characterization of various healthy and diseased tissues, ranging from healthy human kidney to human breast cancer, thus providing a wealth of knowledge. Howeve
21 oct
2022
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Molecular mechanisms of evolutionary innovation
Where do genes come from? All genomes contain genes whose sequences appear unique to a given species or lineage to the exclusion of all others. These “orphan” genes cannot be related to any known gene family; they are considered evolutionarily novel and are thought to mediate species-specific traits and adaptations. In this seminar, I will present an investigation of the evolutionary o
1 avr
2022
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Functions of biomolecular condensates assembled in response to DNA damage
DNA repair mechanisms are crucial for organismal health and survival. All living organisms have evolved a multitude of mechanisms to repair alterations in the primary structure of DNA. DNA damage response (DDR) proteins often accumulate in nuclear foci seemingly similar to biomolecular condensates, but the intrinsic molecular organization and the functions that arise specifically from the assembly
17 déc
2021
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Applied Cybergenetics
Gene expression plays a central role in the orchestration of cellular processes. We recently developed an experimental platform for real-time, closed-loop control of gene expression that integrates microscopy for monitoring gene expression in live cells, microfluidics to manipulate the cells environment, and dedicated software for automated imaging, quantification and model predictive control stra
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