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Unité
ANTONIN MORILLON / VALERIE BORDE
Dynamique de l'information génétique : bases fondamentales et cancer (DIG-Cancer) (UMR3244)

Les équipes de cette unité ont pour objectif de mieux comprendre les mécanismes de maintenance de l’intégrité du génome, tels que la réplication, la réparation et la recombinaison, ainsi que le rôle des mécanismes de contrôle du cycle cellulaire et de l’expression génomique non codante dans la maintenance de l’épigénome.

 

Chiffres-clés
123
Publications depuis 2019
4
ERC depuis 2019
3
Spin-off depuis 2019
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Événements scientifiques
31 mai
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Marie Curie
Cutting and Pasting DNA to Create our Adaptive Immune System
V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/2 recombinase initiates the process by stochastically cleaving DNA at a pair of recombination signal se
8 jan
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Double Raphael - Double Trouble - Double Impact

"How homologous recombination (HR)-deficient tumors survive genomic instability"


 

Abstract

Gaining recognition in the last few years, alternative DNA repair pathways were recently shown to be required for cancer cell viability in the absence of homologous recombination (HR)-mediated DNA repair. Deciphering the functions and composition of these pathways will facilitate
23 nov
2022
Séminaire
09h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Overcoming experimental and computational limitations of multiplexed imaging to study viral infections
Recent technological advances in imaging now allow to simultaneously measure dozens to

hundreds of proteins, either using successive rounds of standard IF imaging or using heavy-metal conjugated antibodies. This has enabled deep spatial characterization of various healthy and diseased tissues, ranging from healthy human kidney to human breast cancer, thus providing a wealth of knowledge. Howeve
21 oct
2022
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Molecular mechanisms of evolutionary innovation
Where do genes come from? All genomes contain genes whose sequences appear unique to a given species or lineage to the exclusion of all others. These “orphan” genes cannot be related to any known gene family; they are considered evolutionarily novel and are thought to mediate species-specific traits and adaptations. In this seminar, I will present an investigation of the evolutionary o
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