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Unité
STEPHAN VAGNER / SARAH LAMBERT
Intégrité du génome, ARN et Cancer (UMR3348)

The research conducted at the « Genome Integrity, RNA and Cancer » Unit explores multiple aspects of genome dynamics that integrate RNA biology in the context of genome maintenance and expression in normal and pathological situations, including cancer.

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25
km de paris
25
nationalités depuis 2015
25
évènements internationaux organisés
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Événements scientifiques
26 avr
2024
Séminaire
11h-12h
Centre de recherche - Orsay - Salle polyvalente du Bâtiment 111
On the multiple roads to cell fate decisions: Integrating transcription factors into RNA-regulatory networks
While the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and cellular diversity. Yet, how the RNA regulatory functions of TFs contribute to their key role in cell fates remains puzzling. From in vitro interaction to tissue development,
21 Mar
2024
Séminaire institutionnel "Mayent - Rothschild"
11h-12h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
A garden of forking paths: branching, switching and reversal in meiotic recombination
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynamism during me
15 déc
2023
Séminaire
11h-12h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
The dangerous combination of DNA structures and chromosome gaps: implications for repeat instability and cell survival
The Freudenreich lab uses the yeast Saccharomyces cerevisiae (baker's yeast) as a model organism to study genome instability. In particular, we investigate the molecular basis of two related types of DNA mutations:  repeat expansions and chromosome fragility.  Expansion of repeat sequences is the cause of more than 20 inherited diseases including Huntington's disease, Fragil
15 Sep
2023
Séminaire Orsay series
11h-23h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Exploiting self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
I will present two discoveries from my team dealing with precision medicine approaches and possibilities. The first part deals with widely used genotoxic cancer therapy, such as irradiation. These modalities operate through extensive induction of DNA breaks, yet cancer cells frequently display resistance to such interventions. Intriguingly, studies following the dynamics of radiation-induced DNA l
11 Juil
2023
Séminaire institutionnel "Mayent - Rothschild"
11h-23h
Centre de recherche - Orsay - Amphithéâtre du Bâtiment 111
Melanoma metastatic niche formation: extracellular vesicles, miRNA, immune, CAF and more
Melanoma initiate at the epidermis and become metastatic once invade into the dermis. We present mutation independent trigger of melanoma switch into the invasive dermal phenotype from the radial dermal growth. We further showed how melanoma cells shape the tumor microenvironment by the trafficking of miRNA via large extracellular vesicles.  In recent work we found melanoma interactions with
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