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Unité
ANA-MARIA LENNON DUMENIL / OLIVIER LANTZ
Immunité et Cancer (U932)

Créée en 2005, l’Unité U932 INSERM est composée de 10 équipes, réparties sur deux bâtiments (Hôpital Curie et Bâtiment Constant-Burg, rue Lhomond), regroupant environ 120 personnes.

Les équipes de l’Unité tentent de mieux comprendre les réponses immunitaires, et d’apprendre au système immunitaire à mieux lutter contre les agents pathogènes et/ou les tumeurs. Les projets de recherche vont de l’immunologie fondamentale à l’immunothérapie translationnelle et à l’immunothérapie clinique chez des patients atteints de cancer.

 

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334
Publications depuis 2017
7
ERC depuis 2008
3
start-ups
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Événements scientifiques
27 Mar
2024
Séminaire
15h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Regulation and immunotherapy responses of NK cells (and T cells) against tumors
Most immunotherapy efforts aim to mobilize CD8+ T cells against cancer cells. Many tumors lack many neoantigens, and others are selected for partial or complete loss of MHC I, even before immunotherapy intervention.  Checkpoint immunotherapy further exacerbates this problem as it preferentially amplifies CD8 cytotoxic effector cell activity, which targets MHC I presented tumor epitopes, impos
19 Mar
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Hélène Martel-Massignac (BDD)
Microbiota-immune interactions in health and disease
Commensal microbes induce tissue-resident T cells, but the function of these T cells is not well understood. In this lecture I will present our latest data on the role of commensal Th17 cells in mucosal homeostasis and host physiology. I will explore how commensal Th17 cells in the small intestinal lamina propria participate in local mucosal protection and the molecular and cellular mechanisms inv
30 juin
2023
Séminaire institutionnel "Mayent - Rothschild"
14h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Type I IFNs in health and disease: from trisomy 21 to cancer
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. We will discuss our results by addressing the biology of IFN in Down syndrome (DS). This syndrome is the consequence of a chromosomal anomaly known as "trisomy 21" in which chromosome 21 is partially or totally tripled. The subunits that make up
20 juin
2023
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Understanding immune aging in mice and humans
Dr. Artyomov will present  his work in immune aging where his laboratory using characterized immune aging in mouse tissues identifying GZMK+ CD8 T cells as uniform hallmark of aging. In parallel effort profiling of human circulating immune cells revealed existence of dedicated GZMK+ CD8 effector memory T cells in the peripheral blood that accumulate with age. We will discuss their transcripti
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