Unité

Immunité et Cancer (U932)

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Unité U932 Immunité et Cancer, Retraite d'Unité 2021, Normandie

Unité U932 Immunité et Cancer, Retraite d'Unité 2021, Normandie

Créée en 2005, l’Unité U932 INSERM est composée de 10 équipes, réparties sur deux bâtiments (Hôpital Curie et Bâtiment Constant-Burg, rue Lhomond), regroupant environ 160 personnes.

Les équipes de l’Unité tentent de mieux comprendre les réponses immunitaires, et d’apprendre au système immunitaire à mieux lutter contre les agents pathogènes et/ou les tumeurs. Les projets de recherche vont de l’immunologie fondamentale à l’immunothérapie translationnelle et à l’immunothérapie clinique chez des patients atteints de cancer.

 

Chiffres-clés
334
Publications depuis 2017
11
ERC depuis 2008
3
start-ups
Publications clés
  • Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages
    Nature Aging
    Nilushi S. De Silva, Johan Siewiera, Chantal Alkhoury, Guilherme P. F. Nader, Francesca Nadalin, Kevin de Azevedo, Mickaël Couty, Helena M. Izquierdo, Anvita Bhargava, Cécile Conrad, Mathieu Maurin, Konstantina Antoniadou, Charles Fouillade, Arturo Londono-Vallejo, Rayk Behrendt, Karine Bertotti, Cindy Serdjebi, François Lanthiez, Lisa Gallwitz, Paul Saftig, Beatriz Herrero-Fernández, Angela Saez, José María González-Granado, Guillaume van Niel, Alexandre Boissonnas, Matthieu Piel, Nicolas Manel
  • Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements
    Science Immunology
    Marianne Burbage, Ares Rocañín-Arjó, Blandine Baudon, Yago A. Arribas, Antonela Merlotti, Derek C. Rookhuizen, Sandrine Heurtebise-Chrétien, Mengliang Ye, Alexandre Houy, Nina Burgdorf, Guadalupe Suarez, Marine Gros, Benjamin Sadacca, Montserrat Carrascal, Andrea Garmilla, Mylène Bohec, Sylvain Baulande, Bérangère Lombard, Damarys Loew, Joshua J. Waterfall, Marc-Henri Stern, Christel Goudot, Sebastian Amigorena
  • Epithelial colonization by gut dendritic cells promotes their functional diversification
    Immunity
    Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
  • Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption
    Cell
    Aleksandra S. Chikina, Francesca Nadalin, Mathieu Maurin, Mabel San-Roman, Thibault Thomas-Bonafos, Xin V. Li, Sonia Lameiras, Sylvain Baulande, Sandrine Henri, Bernard Malissen, Livia Lacerda Mariano, Jorge Barbazan, J. Magarian Blander, Iliyan D. Iliev, Danijela Matic Vignjevic, Ana-Maria Lennon-Duménil
  • Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
    Cancer Cell
    Amaury Leruste, Jimena Tosello, Rodrigo Nalio Ramos, Arnault Tauziède-Espariat, Solène Brohard, Zhi-Yan Han, Kevin Beccaria, Mamy Andrianteranagna, Pamela Caudana, Jovan Nikolic, Céline Chauvin, Leticia Laura Niborski, Valeria Manriquez, Wilfrid Richer, Julien Masliah-Planchon, Sandrine Grossetête-Lalami, Mylene Bohec, Sonia Lameiras, Sylvain Baulande, Celio Pouponnot, Aurore Coulomb, Louise Galmiche, Didier Surdez, Nicolas Servant, Julie Helft, Christine Sedlik, Stéphanie Puget, Philippe Benaroch, Olivier Delattre, Joshua J. Waterfall, Eliane Piaggio, Franck Bourdeaut
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Actualités
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Événements scientifiques
21 mai
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Nucleosomes and DNA methylation – implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancers
DNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation at heterochromatin. Of four proteins whose mutation cause ICF syndromes (DNMT3B, ZBTB24, CDCA7 and HEL
13 mai
2024
Séminaire
11h-23h
Hôpital site de Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
“Deconstruct-Reconstruct” – Decode cancer-immune crosstalk & probe with organoids.
The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are deeply interested in the cellular networks that underpin autoimmune diseases and cancer, which I will ta
3 mai
2024
Séminaire
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Understanding and modeling aging
Aging is associated with a decline in tissue function and the onset of a constellation of diseases. We are interested in understanding aging, with a particular focus on brain aging. Because aging is complex, we use organisms with diverse lifespans – the worm C. elegans, the African killifish, the mouse, and cells from mice and humans. We are interested in identifying epigenetic and metabolic
27 Mar
2024
Séminaire
15h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Regulation and immunotherapy responses of NK cells (and T cells) against tumors
Most immunotherapy efforts aim to mobilize CD8+ T cells against cancer cells. Many tumors lack many neoantigens, and others are selected for partial or complete loss of MHC I, even before immunotherapy intervention.  Checkpoint immunotherapy further exacerbates this problem as it preferentially amplifies CD8 cytotoxic effector cell activity, which targets MHC I presented tumor epitopes, impos
25 Mar
2024
Séminaire Immunology series
11h-23h
Centre de recherche - Paris - Amphithéâtre Constant-Burg - 12 rue Lhomond, Paris 5e
Structural neutrophils
Tissues are composed of cells from different lineages that fulfil different roles needed for organ function. As technologies develop and we expand the palette of immune functions, however, the functional divide between lineages disappear. In this talk I will provide an example that illustrates the blurry division between labor and lineage, and showcase the example of skin neutrophils which we find
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